University of Pennsylvania
This project involves the expansion of the Cyclotron Laboratory for the University of Pennsylvania’s School of Medicine. The Laboratory is located in an underground, highly constrained site situated between the Fagin School of Nursing and the Stellar Chance Laboratories. Above the facility is an existing public park used for pedestrian circulation. About 60% of the existing plaza over the facility will have to be ...
| Square Footage: | 3,000 SF | |
| Construction Budget: | $5,000,000 | |
| Location: | Philadelphia, PA |
University of Pennsylvania
Construction Budget: $5,000,000
Location: Philadelphia, PA
The Cyclotron Facility is a small drug manufacturing facility that produces a biologically active molecule with a positron emitting radionuclide for use in PET Scanners or PET CT Scanners. The primary expansion elements involve the installation of a second cyclotron with an external target station. Both of these are housed in significant new concrete vaults that provide radiation shielding. In addition, new class 10,000 GMP modular labs housing new hot cells for the production of radiopharmacology products will be constructed. A mechanical and electrical mezzanine will be inserted above the manufacturing labs and a new entry pavilion will be located at the front of the labs providing personnel entry material loading/unloading capability.
The entire structure will be poured-in-place concrete and waterproofed. The concrete will be a conventional mix with the walls being load bearing, reinforced concrete of 4’-11” (1.5m) thickness. The concrete roof will be 7’-3” (2.2m) thick. These tentative shielding thicknesses have been established by the University, specifically the users working in conjunction with Environmental Health & Radiation Safety.
In front of the existing vault, two new vaults will be constructed; one for the cyclotron and the other for an external target. The design standards provided by the cyclotron vendor, IBA, have been used for the design of these rooms. Radiation shielding is a critical safety consideration and will be provided by the surrounding concrete structure. The concrete will be a conventional mix with the walls being load bearing, reinforced concrete of 4’-11” (1.5m) thickness. The concrete roof will be 7’-3” (2.2m) thick. These tentative shielding thicknesses have been established by the University, specifically the users working in conjunction with Environmental Health & Radiation Safety.
A system of 12 inch (30cm) deep trenches will be provided below and around the cyclotron allowing connections to be made back to the Power Supply Room. Additional penetrations through the concrete walls are also necessary. These will be “chevron” shaped to create a “maze” configuration. Using “S” shaped conduit the new concrete walls will be formed to match the existing vault penetrations. However, new penetrations through the existing concrete wall will have to be drilled from both sides forming a “V” shape

